The result declared by MPPSC results contains the roll number of the candidates selected for an interview. It shows a total of 800 candidates, who have successfully cleared the test, and 659 have been selected for recruitment towards 204 posts in Part A.

The MPPSC exam 2023 was conducted from March 11 to March 16 2024 to fill a total of 229 vacancies. Candidates will be able to check the result on the official website by entering login credentials.

Candidates who have qualified for the MPPSC state service mains exam 2023 have to appear in the interview round for final selection. The interview round will be conducted for 185 marks. The final selection will be made on the basis of the total score of the mains and interview which is 1,685.

• Click on the official website of MPPSC, mppsc.mp.gov.in.
• Then click on the link to the MPPSC State Service Mains Exam 2023 Result link available on the homepage.
• A new page will open. Then check your roll number in the PDF.
• Candidates can download the result PDF for reference in the future.
• The MPPSC State Service Mains exam was conducted at Indore, Bhopal, Gwalior, Jabalpur, Chhindwara, Ratlam, Satna, Sagar, Shahdol, Barwani, and Balaghat.

The number of 229 posts includes 72 UR, 36 SC, 44 ST, 55 OBC, and 22 EWS. Below is the pattern and marking scheme for the exam.

Also Read: Final Opportunity for Registration with NBEMS for Trainees of the 2023 Admission Session 

Conclusion

The declaration of State Service Mains Exam 2023 MPPSC results marks an important milestone for aspirants aspiring to join the administrative services of Madhya Pradesh. With 800 candidates shortlisted for interviews and 204 posts in Part A, the competition moves to the next stage. Candidates should prepare well for the interview round which plays a crucial role in the final selection. For further updates and result-related information, keep checking the official MPPSC website. Good luck to all the candidates!

This innovative hydrogel-based therapy delivers anti-cancer drugs directly to tumor sites, significantly reducing the side effects typically associated with conventional cancer treatments.

The paper is co-authored by Prof. Debapratim Das, along with his research scholars Ms. Tanushree Das and Ms. Ritvika Kushwaha from IIT Guwahati, and collaborators Dr. Kuldip Jana, Mr. Satyajit Halder, and Mr. Anup Kumar Misra from Bose Institute Kolkata.

Surgical removal of tumors is sometimes not feasible, particularly for internal organs, while chemotherapy’s systemic delivery often results in harmful side effects by affecting both cancerous and healthy cells.

Design

Prof. Debpratim Das, Department of Chemistry, and his team at IIT Guwahati addressed these challenges by designing a hydrogel that delivers drugs precisely to the tumor site, ensuring localized action.

Water-based

Hydrogels are water-based, three-dimensional polymer networks capable of absorbing and retaining fluids. Their unique structure mimics living tissues, making them suitable for biomedical applications.

This newly developed hydrogel acts as a stable reservoir for anti-cancer drugs and releases them in a controlled manner, responding to specific conditions in the tumor microenvironment, say researchers from IIT Guwahati.

It responds to elevated glutathione (GSH) levels, a molecule abundant in tumor cells.

Upon encountering high GSH levels, the hydrogel triggers a controlled drug release directly into the tumor, minimizing its interaction with healthy tissues and reducing systemic side effects, say sources from IIT Guwahati.

Department of Chemistry at IIT Guwahati

Speaking about the breakthrough, Prof. Debapratim Das, Dept. of Chemistry, IIT Guwahati, said, “This work exemplifies how scientific innovation can directly address the pressing needs of cancer treatment.

The hydrogel’s unique properties allow it to work in harmony with the biological environment, offering precision where it is needed most, said Prof Debapratim Das of IIT Guwahati.

We are excited by its potential to transform our thoughts about localized drug delivery, he said.

Preclinical trials

In preclinical trials on a murine model of breast cancer, the hydrogel showcased remarkable efficacy.

A single injection of the hydrogel, loaded with the chemotherapy drug Doxorubicin, resulted in a ~75% reduction in tumor size within 18 days.

Crucially, the hydrogel remained localized at the tumor site, steadily releasing the drug over time without causing detectable side effects on other organs.

Delivery system

This innovative delivery system enhances the drug’s effectiveness while reducing the required dosage, thus minimizing toxicity.

Laboratory studies further demonstrated that the hydrogel improves drug uptake by cancer cells, induces cell cycle arrest, and promotes programmed cell death, thereby attacking tumors on multiple fronts.

Further studies

Further studies are going on to find out the maximum amount of reduction in the size of the tumor by a single dose. Moreover, we are also looking into other types of tumors, say sources from IIT Guwahati.

Once all the studies are complete, will apply to take the material for clinical trial and are looking for an appropriate partner to do the same.

At present, the Institute has eleven departments, nine interdisciplinary academic centres and five schools.

They are covering all the major engineering, science, healthcare, management, and humanities disciplines, offering BTech, BDes, BSc(Hons), MA, MDes, MTech, MSc, MS(R), MBA and PhD programmes.

The institute offers a residential campus to 455 faculty members and more than 8,600 students at present.

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