Professor Pranita is from Department of Biosciences and Bioengineering at IIT Roorkee. This study by IIT Roorkee researchers funded by BioCARe Women Scientist grant and Innovative Young Biotechnologist Award grant from the Department of Biotechnology of Government of India has provided important insights into the role of immune cell markers on sepsis-related complications.

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As a result, these cells form ensembles, move around the body, and get deposited in important organs such as the lung, kidney, and liver, which could lead to multi-organ failure or even death.

IIT Roorkee researchers

Speaking about her research, Professor Pranita P Sarangi said Given the importance of monocytes, macrophages and neutrophils in sepsis, it is important to understand the mechanism of the migration of such cells to detect the stages of inflammation and sepsis.

This binding occurs via receptor molecules called integrins that are present on the cell surfaces. The integrin receptors enable communication between the immune cells and the surrounding matrix, which helps in cell migration and modulation of other functions. However, their over-activity (called hyper-activation), can result in problems, say IIT Roorkee researchers.

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Once inside the tissues, these monocytes further mature into macrophages and by sensing the signals from the septic environment, these cells gradually switch their functions from inflammatory to immunosuppressive subtype that correlate with their integrin expression profile, say IIT Roorkee researchers.

Findings
These findings will help in detecting the stages of sepsis and appropriate treatment, said the lead researcher, Mr. Shiba Prasad Dash, who is currently perusing his PhD under the guidance of Professor Sarangi.

Results
Results from this work by IIT Roorkee researchers have been published in The Journal of Immunology, the official journal of the American Association of Immunologists (AAI) and presented at the international conferences organized by the Indian Immunology Society (Immunocon-2019).

IIT Roorkee is an institute of national importance imparting higher education in engineering, sciences, management, architecture and planning, and humanities and social sciences. Since its establishment in 1847, the Institute has played a vital role in providing technical human resources and know-how to the country.

The vision of the institution is to attain global level of excellence in education and to create a sustainable and equitable society through innovative research in science and technology.

The mission of IIT Roorkee is to create an environment that shall foster the growth of intellectually capable, innovative and entrepreneurial professionals, who shall contribute to the growth of Science and Technology in partnership with industry and develop and harness it for the welfare of the nation and mankind.

The beginning is with JEE Mains which is conducted two times every year, candidates who pass it can get admission in NITs, IIITs in engineering courses offered there.

Every year lot of students try to appear for JEE Advanced exam and pass it to become eligible for IIT admission, this is because, a degree from IIT opens the gates to a very bright future.

The aim of this article on JEE Advanced 2025 preparation is to help students inform about the exam and help them form a good JEE Advanced 2025 preparation strategy. More details are mentioned below:

Exam pattern

Things start with knowing how the exam is conducted, once students know this, they can then devise a superb JEE Advanced 2025 preparation plan. The exam pattern of JEE Advanced is mentioned below:

Before diving into JEE Advanced 2025 preparation, it’s crucial to understand the exam pattern. The test consists of two papers:

1. Paper 1: 3 hours, 54 questions
2. Paper 2: 3 hours, 54 questions

The total marks for each paper are 180 and both papers have a total score of 360.

Creating a JEE Advanced 2025 Preparation Plan

To develop an effective JEE Advanced 2025 preparation plan, follow these steps:

1. Set realistic goals: Break down your study material into manageable chunks, and set achievable goals for each study session.
2. Identify your weaknesses: Focus on improving your weak areas, and allocate more time to those subjects.
3. Allocate time wisely: Divide your study time into three sections: Physics, Chemistry, and Mathematics.

1. NCERT textbooks: Focus on NCERT textbooks for all three subjects, as they provide a solid foundation.
2. Reference books: Supplement your NCERT textbooks with reference books like RD Sharma, SL Loney, and OP Tandon.
3. Online resources: Utilize online resources like Khan Academy, Unacademy, and BYJU’S for additional study materials.

Practice and Revision for JEE Advanced 2025 Preparation

Practice and revision are crucial components of JEE Advanced 2025 preparation. Follow these tips:

1. Take mock tests: Regularly take mock tests to assess your knowledge, identify weak areas, and improve your time management skills.
2. Practice previous year’s papers: Practice previous year’s papers to get familiar with the exam pattern and question types.
3. Create revision notes: Create concise revision notes for each subject, highlighting key concepts and formulas.

Time Management

Effective time management is essential for JEE Advanced preparation. Follow these tips:

1. Create a schedule: Plan out your study schedule in advance, allocating specific times for each subject.
2. Use time-blocking: Divide your study time into focused blocks, eliminating distractions during each block.
3. Take breaks: Take regular breaks to avoid burnout and maintain a healthy work-life balance.

Staying Motivated for JEE Advanced 2025 Preparation

Staying motivated is crucial for JEE Advanced 2025 preparation. Follow these tips:

1. Remind yourself of your goals: Keep your goals in mind, and remind yourself why you’re working towards JEE Advanced 2025.
2. Celebrate small victories: Reward yourself for small milestones achieved during your JEE Advanced 2025 preparation journey.
3. Seek support: Surround yourself with supportive friends and family, and consider joining a study group for motivation.

By incorporating these final tips into your JEE Advanced 2025 preparation strategy, you’ll be well on your way to achieving success.

Conclusion

JEE Advanced 2025 preparation requires a strategic plan, dedication, and hard work. By following the steps outlined in this article, you’ll be well-prepared to crack JEE Advanced 2025. Remember to stay focused, motivated, and committed to your goals. With persistence and perseverance, you’ll achieve success in JEE Advanced 2025.

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