Professor Pranita is from Department of Biosciences and Bioengineering at IIT Roorkee. This study by IIT Roorkee researchers funded by BioCARe Women Scientist grant and Innovative Young Biotechnologist Award grant from the Department of Biotechnology of Government of India has provided important insights into the role of immune cell markers on sepsis-related complications.

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As a result, these cells form ensembles, move around the body, and get deposited in important organs such as the lung, kidney, and liver, which could lead to multi-organ failure or even death.

IIT Roorkee researchers

Speaking about her research, Professor Pranita P Sarangi said Given the importance of monocytes, macrophages and neutrophils in sepsis, it is important to understand the mechanism of the migration of such cells to detect the stages of inflammation and sepsis.

This binding occurs via receptor molecules called integrins that are present on the cell surfaces. The integrin receptors enable communication between the immune cells and the surrounding matrix, which helps in cell migration and modulation of other functions. However, their over-activity (called hyper-activation), can result in problems, say IIT Roorkee researchers.

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Once inside the tissues, these monocytes further mature into macrophages and by sensing the signals from the septic environment, these cells gradually switch their functions from inflammatory to immunosuppressive subtype that correlate with their integrin expression profile, say IIT Roorkee researchers.

Findings
These findings will help in detecting the stages of sepsis and appropriate treatment, said the lead researcher, Mr. Shiba Prasad Dash, who is currently perusing his PhD under the guidance of Professor Sarangi.

Results
Results from this work by IIT Roorkee researchers have been published in The Journal of Immunology, the official journal of the American Association of Immunologists (AAI) and presented at the international conferences organized by the Indian Immunology Society (Immunocon-2019).

IIT Roorkee is an institute of national importance imparting higher education in engineering, sciences, management, architecture and planning, and humanities and social sciences. Since its establishment in 1847, the Institute has played a vital role in providing technical human resources and know-how to the country.

The vision of the institution is to attain global level of excellence in education and to create a sustainable and equitable society through innovative research in science and technology.

The mission of IIT Roorkee is to create an environment that shall foster the growth of intellectually capable, innovative and entrepreneurial professionals, who shall contribute to the growth of Science and Technology in partnership with industry and develop and harness it for the welfare of the nation and mankind.

It is a highly competitive exam that requires thorough preparation. If you’re planning to appear for NEET PG 2025, it’s essential to have a well-planned study strategy.

Exam Pattern

The NEET PG exam consists of 300 multiple-choice questions (MCQs) from various subjects, including clinical subjects, pre-clinical subjects, and para-clinical subjects.

NEET PG 2025 preparation books

NEET PG 2025 preparation books is about the books that are required to study as a part of NEET PG 2025 preparation. Some of the recommended books for NEET PG 2025 preparation include:

– Textbooks: Robbins and Cotran’s Pathologic Basis of Disease, Guyton and Hall Textbook of Medical Physiology, and Harrison’s Principles of Internal Medicine.

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NEET PG 2025 Preparation Study Plan

NEET PG 2025 study plan is about the strategy that focuses on planned study of various chapters in subjects related to medicine.

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2. Create a Schedule: Allocate time for each subject, and prioritize topics that need more attention.

3. Focus on Weak Areas: Identify your weak areas and focus on improving them.

4. Practice Regularly: Practice regularly, and review what you’ve studied.

Preparation Plan

Here’s a sample preparation plan for NEET PG preparation:

– Phase 1: Focus on building a strong foundation in each subject.

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Last-Minute Strategies

Here are some last-minute strategies to follow for NEET PG preparation:

– Focus on High-Yield Topics: Focus on high-yield topics that are frequently asked in the exam.

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– Stay Calm and Focused: Stay calm and focused, and avoid last-minute cramming.

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