IIT Mandi researchers show great drug can reverse type 2 diabetes

IIT Mandi researchers show great drug can reverse type 2 diabetes
Published at : 3 Nov 2020, 10:21 AM IST
Updated at : 3 Nov 2020, 2:16 PM IST

IIT Mandi researchers have shown that drug used to treat opioid addiction can also potentially reverse some of adverse events related to type 2 diabetes.

This work taken up by IIT Mandi researchers got funding from Science and Engineering Research Board (SERB), the result of this work has been published in the Journal of Biological Chemistry.

Admission Open in Amity for 2025
IIT Mandi researchers

IIT Mandi researchers said Insulin, a hormone produced by the pancreas, is used by cells to absorb glucose from the blood.

IIT Mandi researchers further said Type-2 Diabetes is caused when cells lose their ability to use insulin due to a variety of reasons.

Insulin resistance is intricately linked to a condition called hyperinsulinemia, in which there is excess insulin traversing the bloodstream.

Admission Open in SRM for 2025

The relationship between insulin resistance and hyperinsulinemia is cyclic – each increases the occurrence of the other.

While it is obvious how insulin resistance leads to hyperinsulinemia – when cells cannot use the insulin, it just remains in the blood – the converse of how hyperinsulinemia increases insulin resistance has hitherto remained unclear.

One of IIT Mandi researchers Dr. Mondal said they have known that one of the causes of insulin resistance is inflammation.

Admission Open in LPU for 2025

‘We wanted to find out if and how hyperinsulinemia invokes inflammation in the body, which would provide the link between the two conditions.’

IIT Mandi researchers have identified a critical protein molecule – SIRT1 which is repressed in hyperinsulinemia.

They discovered that a decrease in SIRT1 activates another protein called NFkB, which instigates inflammation, thus providing the link between hyperinsulinemia and systemic inflammation.

IIT Mandi researchers have also found a solution to this problem.

Admission Open in VIT for 2025
IIT Mandi researchers

The significance of this discovery is enormous, say IIT Mandi researchers.

‘Naltrexone at low doses could potentially restore some of the diabetes-associated events in cellular and animal models,’ says Dr. Mondal.

Dr. Mondal is confident that this is a viable path to follow for Type-2 diabetes management.

‘Naltrexone is already an FDA-approved drug that is used for the treatment of opioid addiction and can easily be repurposed for inflammation reduction and diabetes control,’ says Dr. Mondal who is one of IIT Mandi researchers.

IIT Mandi researchers intend to study this thread further, to understand the mechanistic aspects of LDN’s effects on hyperinsulinemia-induced inflammation and resulting insulin resistance.

The study by the IIT Mandi researchers and its collaborators is timely given the urgent need to understand and address the issue of diabetes in India.

India is the diabetes capital of the world,’ says Dr. Mondal one of the IIT Mandi researchers.

He said that one of every six diabetics in the world is Indian.

‘It is important to understand the various causative factors for diabetes to find cures and management strategies,’ says Dr. Mondal whose work seeks to understand and treat insulin resistance.

Since the first batch of 97 students joined in July 2009, IIT Mandi has grown to currently host 125 faculty and 1,655 students who are enrolled in various programmes of studies in undergraduate, postgraduate and research programmes, and 1,141 alumni.

IIT Mandi is a fully residential campus with 1.4 lakh sq. m. buildings completed. It has a guest house with 88 rooms, an 750-seater Auditorium, campus school, sports complex and hospital.

IIT Mandi has four Academic Schools and three major Research Centers. The Schools are: School of Computing and Electrical Engineering, School of Basic Sciences, School of Engineering, and School of Humanities and Social Sciences.

The Centers are: Advanced Materials Research Centre (AMRC; set up with an investment of Rs. 60 crore), Centre for Design and Fabrication of Electrical Devices (C4DFED; has Rs. 50 crore worth of fabrication tools), and BioX Centre (has acquired research equipment worth Rs. 15 crore).

IIT Mandi researchers

To cater to the growing and changing needs of Indian industry and the aspirations of students, IIT Mandi has introduced 7 B.Tech., 7 M.Tech., 5 M.Sc., 4 Ph.D., 1 I-Ph.D and 1 M.A programmes in the past 10 years.

The unique, project-oriented B.Tech. curriculum is centered around its 4-year long Design and Innovation stream. From August 2019, IIT Mandi started 3 new and unique B. Tech. programmes in Data Science and Engineering, Engineering Physics, and Dual Degree in Bioengineering.

Since the inception of the Institute, IIT Mandi faculty have been involved in over 275 Research and Development (R&D) projects worth more than Rs. 120 crore. In the past 10 years, the Institute has signed Memorandum of Understanding (MoU) with as many as 11 international and 12 national universities.

 

S.
S. Vishnu Sharma

S Vishnu Sharmaa now works with collegechalo.com in the news team. His work involves writing articles related to the education sector in India with a keen focus on higher education issues. Journalism has always been a passion for him. He has more than 10 years of enriching experience with various media organizations like Eenadu, Webdunia, News Today, Infodea. He also has a strong interest in writing about defence and railway related issues.

JIPMAT 2025 registration on till 10 March 2025, Info and Links Available Here

JIPMAT 2025 registration on till 10 March 2025, Info and Links Available Here
Published at : 13 Feb 2025, 12:38 PM IST
Updated at : 13 Feb 2025, 12:42 PM IST

JIPMAT 2025 registration is on till 10 March 2025 at ‘https://exams.nta.ac.in/JIPMAT/’

Registration is nothing but applying for the exam. The application submission process was opened on 11 February 2025.

Admission Open in Amity for 2025
JIPMAT 2025 Registration

Schedule

Individuals can take up JIPMAT 2024 registration from 11 February 2025 to 10 March 2025 (11:50) PM.

Fees in connection with JIPMAT 2025 registration can be paid till 11:50 PM on 11 March 2025.

The corrections in application forms already submitted can be done from 13 to 15 March 2025.

Admission Open in SRM for 2025

Candidates can make corrections in the details submitted by them in their application online through the correction window at ‘https://exams.nta.ac.in/JIPMAT/’ during the period when the correction/editing window is made available.

The date for announcing the city of examination will be informed later on the official website of the exam. The exam will be conducted on 26 April 2025.

Admission Open in LPU for 2025

What is JIPMAT 2025?

The full name of the exam is Joint Integrated Programme in Management Admission Test (JIPMAT).

It is a national-level entrance examination for admission to 5-Year integrated program in management in IIM Bodh Gaya and IIM Jammu.

The admission is for the academic year 2025-26. It is a computer-based test conducted for a duration of 150 minutes or 2 hours 30 minutes.

Answers have to be marked on a computer screen at the designated test centre. There is more to it than meets the eye as far as JIPMAT 2025 registration is concerned.

Admission Open in VIT for 2025

Who can take up JIPMAT 2025 registration?

Candidates who have passed plus two in any stream from a recognized educational institution can take up JIPMAT 2025 registration.

The candidate must have passed class 10th examination with required qualifying marks. They must also have passed class 12 exams with required qualifying marks.

Candidates should have passed 10+2/XII/HSC examination in arts/commerce/science stream or equivalent in the year 2023, 2024 or is appearing in 2025.

The candidate must have passed class 10th examination in the year not before 2021.

The IIMs (Bodh Gaya and Jammu) may have different eligibility requirements, the candidates are required to refer to the website of IIM Bodh Gaya and IIM Jammu for this.

The percentage of marks obtained by the candidate in 10th and 12th standards would be calculated based on the Board’s regulations.

If there is no such regulation regarding aggregate marks from the concerned board, then the aggregate marks of all the subjects that appear in the grade sheet should be considered for calculating the passing percentage.

JIPMAT 2025 Registration

1. The URL mentioned above has to be typed into the browser and the webpage must be allowed to download.

2. Once the webpage is downloaded, candidates can read the information about the exam through the information bulletin.

3. After reading the information, they can click the button JIPMAT-2025: Click Here to Register/Login

4. Clicking the above button will open another webpage with URL ‘https://jipmat2025.ntaonline.in/site/login’

5. When webpage with above URL opens, candidates can click the button New Candidate Register Here and create an account.

6. After creating an account, they can come back to the webpage ‘https://jipmat.ntaonline.in/frontend/web/’ and login and start JIPMAT 2025 registration.

JIPMAT 2025 Registration Fee

JIPMAT 2025 registration fee is Rs 2000 for male and female applicants from the General (UR)/OBC-NCL categories. Third Gender/EWS/SC/ST/PwD category applicants have to pay Rs 1000 while undertaking JIPMAT 2025 registration.

Those willing to take up the exam in foreign countries have to pay Rs 10,000 while taking up JIPMAT 2025 registration.

JIPMAT 2025 Registration

The process to download admit cards is online, candidates have to visit the official website and the URL to access the official website is ‘https://exams.nta.ac.in/JIPMAT/’

1. Above mentioned URL can be typed into the browser and then the webpage is to be allowed to download.

2. Once the website is available, candidates can click the link for admit card.

3. Clicking the above link, will likely open another webpage, when that opens, they have to enter their roll number, application number and other information and submit them to view the admit card.

The Exam

They must appear for the exam at the test centre chosen by them. Questions related to Quantitative Aptitude, Data Interpretation and Logical Reasoning, Verbal Ability and Reading Comprehension have to be answered.

Students who pass JIPMAT 2025 with the required qualifying marks can apply for admission.

They can also visit the official websites of the participating institutions to know more information about courses offered there.

The admit card can be downloaded and a printout can be taken and preserved for use during the exam.

S.
S. Vishnu Sharma

S Vishnu Sharmaa now works with collegechalo.com in the news team. His work involves writing articles related to the education sector in India with a keen focus on higher education issues. Journalism has always been a passion for him. He has more than 10 years of enriching experience with various media organizations like Eenadu, Webdunia, News Today, Infodea. He also has a strong interest in writing about defence and railway related issues.



Whatsapp