IIT Mandi researchers show great drug can reverse type 2 diabetes

IIT Mandi researchers show great drug can reverse type 2 diabetes
Published at : 3 Nov 2020, 10:21 AM IST
Updated at : 3 Nov 2020, 2:16 PM IST

IIT Mandi researchers have shown that drug used to treat opioid addiction can also potentially reverse some of adverse events related to type 2 diabetes.

This work taken up by IIT Mandi researchers got funding from Science and Engineering Research Board (SERB), the result of this work has been published in the Journal of Biological Chemistry.

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IIT Mandi researchers

IIT Mandi researchers said Insulin, a hormone produced by the pancreas, is used by cells to absorb glucose from the blood.

IIT Mandi researchers further said Type-2 Diabetes is caused when cells lose their ability to use insulin due to a variety of reasons.

Insulin resistance is intricately linked to a condition called hyperinsulinemia, in which there is excess insulin traversing the bloodstream.

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The relationship between insulin resistance and hyperinsulinemia is cyclic – each increases the occurrence of the other.

While it is obvious how insulin resistance leads to hyperinsulinemia – when cells cannot use the insulin, it just remains in the blood – the converse of how hyperinsulinemia increases insulin resistance has hitherto remained unclear.

One of IIT Mandi researchers Dr. Mondal said they have known that one of the causes of insulin resistance is inflammation.

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‘We wanted to find out if and how hyperinsulinemia invokes inflammation in the body, which would provide the link between the two conditions.’

IIT Mandi researchers have identified a critical protein molecule – SIRT1 which is repressed in hyperinsulinemia.

They discovered that a decrease in SIRT1 activates another protein called NFkB, which instigates inflammation, thus providing the link between hyperinsulinemia and systemic inflammation.

IIT Mandi researchers have also found a solution to this problem.

Admission Open in VIT for 2025
IIT Mandi researchers

The significance of this discovery is enormous, say IIT Mandi researchers.

‘Naltrexone at low doses could potentially restore some of the diabetes-associated events in cellular and animal models,’ says Dr. Mondal.

Dr. Mondal is confident that this is a viable path to follow for Type-2 diabetes management.

‘Naltrexone is already an FDA-approved drug that is used for the treatment of opioid addiction and can easily be repurposed for inflammation reduction and diabetes control,’ says Dr. Mondal who is one of IIT Mandi researchers.

IIT Mandi researchers intend to study this thread further, to understand the mechanistic aspects of LDN’s effects on hyperinsulinemia-induced inflammation and resulting insulin resistance.

The study by the IIT Mandi researchers and its collaborators is timely given the urgent need to understand and address the issue of diabetes in India.

India is the diabetes capital of the world,’ says Dr. Mondal one of the IIT Mandi researchers.

He said that one of every six diabetics in the world is Indian.

‘It is important to understand the various causative factors for diabetes to find cures and management strategies,’ says Dr. Mondal whose work seeks to understand and treat insulin resistance.

Since the first batch of 97 students joined in July 2009, IIT Mandi has grown to currently host 125 faculty and 1,655 students who are enrolled in various programmes of studies in undergraduate, postgraduate and research programmes, and 1,141 alumni.

IIT Mandi is a fully residential campus with 1.4 lakh sq. m. buildings completed. It has a guest house with 88 rooms, an 750-seater Auditorium, campus school, sports complex and hospital.

IIT Mandi has four Academic Schools and three major Research Centers. The Schools are: School of Computing and Electrical Engineering, School of Basic Sciences, School of Engineering, and School of Humanities and Social Sciences.

The Centers are: Advanced Materials Research Centre (AMRC; set up with an investment of Rs. 60 crore), Centre for Design and Fabrication of Electrical Devices (C4DFED; has Rs. 50 crore worth of fabrication tools), and BioX Centre (has acquired research equipment worth Rs. 15 crore).

IIT Mandi researchers

To cater to the growing and changing needs of Indian industry and the aspirations of students, IIT Mandi has introduced 7 B.Tech., 7 M.Tech., 5 M.Sc., 4 Ph.D., 1 I-Ph.D and 1 M.A programmes in the past 10 years.

The unique, project-oriented B.Tech. curriculum is centered around its 4-year long Design and Innovation stream. From August 2019, IIT Mandi started 3 new and unique B. Tech. programmes in Data Science and Engineering, Engineering Physics, and Dual Degree in Bioengineering.

Since the inception of the Institute, IIT Mandi faculty have been involved in over 275 Research and Development (R&D) projects worth more than Rs. 120 crore. In the past 10 years, the Institute has signed Memorandum of Understanding (MoU) with as many as 11 international and 12 national universities.

 

S.
S. Vishnu Sharma

S Vishnu Sharmaa now works with collegechalo.com in the news team. His work involves writing articles related to the education sector in India with a keen focus on higher education issues. Journalism has always been a passion for him. He has more than 10 years of enriching experience with various media organizations like Eenadu, Webdunia, News Today, Infodea. He also has a strong interest in writing about defence and railway related issues.

UPSC NDA and NA 2 Exam 2025 Registration From 28 May 2025, Details Provided Here

UPSC NDA and NA 2 Exam 2025 Registration From 28 May 2025, Details Provided Here
Published at : 11 Feb 2025, 7:28 PM IST
Updated at : 11 Feb 2025, 7:33 PM IST

UPSC NDA and NA 2 Exam 2025 registration will start from 28 May 2025 at ‘https://upsc.gov.in/’ The applications can be submitted till 17 June 2025.

Candidates keen on a career in the Indian Armed Forces can apply for UPSC NDA and NA 2 Exam 2025. It is to remember that the entrance exam alone will be conducted by Union Public Service Commission (UPSC).

Admission Open in Amity for 2025
UPSC NDA and NA 2 Exam 2025

Candidates who pass NDA and NA 2 Exam 2025 with the required qualifying marks alone will be able to register for the interview. Interview is a process where physical, psychological abilities of the candidates are tested.

After a pass in the physical and psychological tests, the individuals have to pass medical examination.

The final list of selected candidates will be prepared based on their performance in the physical test, psychological test, medical fitness test.

Admission Open in SRM for 2025

Schedule for UPSC NDA and NA 2 Exam 2025

Registration for UPSC NDA and NA 2 Exam 2025 will be going on from 28 May 2024 to 17 June 2024. The other details will be informed when the notification of

Eligibility

Candidates who passed plus two from a recognized educational institution located anywhere in India can take up UPSC NDA and NA 2 Exam 2025 registration which is nothing but applying for the exam.

Those willing to choose Indian Navy or Indian Air Force can preferably have to pass plus two in science stream with subjects as maths, physics and chemistry.

Admission Open in LPU for 2025

Students focused on Indian Army can pass plus two from any stream to take up UPSC NDA and NA 2 Exam 2025 registration.

Candidates wishing to take up UPSC NDA and NA 2 Exam 2025 registration must be an Indian citizen and should be unmarried.

ALSO

Even a subject of Nepal or persons of Indian origin who has migrated to India from Pakistan, Burma, Sri Lanka and East African Countries of Kenya, Uganda, the United Republic of Tanzania, Zambia, Malawi, Zaire and Ethiopia or Vietnam with the intention of permanently settling in India can take up UPSC NDA and NA 2 Exam 2025 registration.

However, subjects of Nepal or persons of Indian origin who have come to India must obtain eligibility certificate from Government of India before applying.

Admission Open in VIT for 2025
UPSC NDA and NA 2 Exam 2025

Registration fee for applying for UPSC NDA and NA 2 Exam 2025 is Rs 100.

SC/ST candidates, Female applicants, wards of JCOs, NCOs, ORs are exempted from payment of application fee for UPSC NDA and NA 2 Exam 2025.

How to apply for UPSC NDA and NA 2 Exam 2025?

The process to apply for UPSC NDA and NA 2 Exam 2025 is online. Applications can be submitted on the official website ‘https://upsc.gov.in/’

1. The URL mentioned above must be typed into the browser and submitted to allow the website to download.

2. Once the website is ready, candidates can click the Exam Notification: National Defence Academy and Naval Academy Examination (II), 2025 button.

3. Clicking the above button will open another webpage

4. Once the webpage with another URL is open, candidates can see the notification about UPSC NDA and NA Exam 2 2025.

5. After knowing all about the exam, they can press the button Click Here located next to the notification button.

6. Clicking the above button will open another webpage with URL ‘https://upsconline.nic.in/upsc/OTRP/’

7. Once the above webpage opens, candidates can click the button New Registration and then create an account to obtain an OTR (One Time Registration) ID and password.

8. After obtaining the credentials, candidates can login using OTR ID and password and then view the list of exams and choose UPSC NDA and NA 2 Exam 2025 and apply for it.

9. The application form has to be filled and registration fee has to be paid and then form has to be submitted.

10. After submission, candidates have to wait for message indicating successful submission. After the message is obtained, candidates can download it and take a print out and preserve it for future use.

UPSC NDA and NA 2 Exam 2025

Candidates can directly access the OTR page and click the New Registration link to take up One Time Registration (OTR). After that, candidates can start filling the form.

S.
S. Vishnu Sharma

S Vishnu Sharmaa now works with collegechalo.com in the news team. His work involves writing articles related to the education sector in India with a keen focus on higher education issues. Journalism has always been a passion for him. He has more than 10 years of enriching experience with various media organizations like Eenadu, Webdunia, News Today, Infodea. He also has a strong interest in writing about defence and railway related issues.



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