The research has conclusively shown that excessive consumption of sugar leads to fatty liver.

IIT Mandi researchers discover great molecular mechanism

NAFLD is a medical condition in which excess fat deposits in the liver.

If left untreated, the excess fat can irritate the liver cells, resulting in scarring of the liver (cirrhosis), and in advanced cases, can even lead to liver cancer.

The treatment of advanced stages of NAFLD is difficult.

IIT Mandi researchers used complementary experimental approaches to establish the underlying biochemical relationship between the consumption of excessive sugar and the development of ‘fatty liver’, medically known as Non-Alcoholic Fatty Liver Disease (NAFLD).

This work by IIT Mandi researchers offers incentive to the public to reduce sugar intake to stop NAFLD in its early stages.

Dr Prosenjit Mondal, Associate Professor, School of basic Sciences led the team of IIT Mandi researchers.

Their work has been published in the journal of Biological Chemistry.

Read More – Easiest exams in India

The research paper has been co-authored by Dr Prosenjit Mondal along with his research scholars, Mr. Vineeth Daniel, Ms. Surbhi Dogra, Ms. Priya Rawat, Mr. Abhinav Choubey from IIT Mandi, in collaboration with Dr. Mohan Kamthan and Ms. Aiysha Siddiq Khan from Jamia Hamdard Institute, New Delhi, along with Mr. Sangam Rajak from SGPGI, Lucknow.

Speaking about the work done by IIT Mandi researchers, Dr. Prosenjit Mondal said the molecular mechanisms that increase hepatic DNL due to overconsumption of sugar have not been clear.

Our goal was to unravel this mechanistic pathway between excessive sugar consumption and onset and development of fatty liver Through DNL, said Dr. Prosenjit who led the team of IIT Mandi researchers.

India is the first country in the world to identify the need for action on NAFLD and with good reason, say IIT Mandi researchers.

The prevalence of NAFLD in India is about 9% to 32% of the population, with the state of Kerala alone having a prevalence of 49% and a staggering 60% prevalence among obese school-going children.

What causes NAFLD? One of the cause is said to be consuming both table sugar and other form of carbohydrates more than the required quantities.

Also read ‘Do you want to know about universities in the great top 10 positions in India in QS World University Rankings for 2022? Click here to know‘

Consumption of excess sugar and carbohydrates causes the liver to convert them into fat in a process called hepatic De Novo Lipogenesis or DNL, which leads to fat accumulation in the liver, say IIT Mandi researchers.

Through a complementary experimental approach involving mice models, the IIT Mandi researchers have shown the hitherto unknown link between the carbohydrate-induced activation of a protein complex called NF-κB and increased DNL.

‘Our data indicates that the sugar-mediated shuttling of hepatic NF-κB p65 reduces the levels of another protein, sorcin, which in turn activates liver DNL through a cascading biochemical pathway,’ said the scientist who lead IIT Mandi researchers.

The unravelling of the molecular link between sugar and fat accumulation in the liver is key to developing therapeutics for the disease.

Team of IIT Mandi researchers have shown that drugs that can inhibit NF-κB can prevent sugar-induced hepatic fat accumulation.

They have also shown that the knockdown of sorcin reduces the lipid-lowering ability of the NF-κB inhibitor.

IIT Mandi researchers’ finding that NF-κB plays a key role in lipid accumulation in the liver opens up a new avenue of therapeutics for NAFLD.

NF-κB also plays a role in other diseases that involve inflammation, such as cancer, Alzheimer’s disease, atherosclerosis, IBS, stroke, muscle wasting and infections and scientists around the world are developing therapeutics that can block NF-κB.

The IIT Mandi research shows that NAFLD can now be added to the repertoire of diseases that can be treated with drugs that block NF-κB.

From the preventive angle, the work of IIT Mandi researchers has conclusively shown that excessive sugar intake leads to a fatty liver.

This should offer incentive to the public to reduce sugar intake to stop NAFLD in its early stages.

About IIT Mandi

Since the first batch of 97 students joined in July 2009, IIT Mandi has grown to currently host 125 faculty and 1,833 students who are enrolled in various programmes of studies in undergraduate, postgraduate and research programmes, and 1516 alumni.

IIT Mandi is a fully residential campus with 1.4 lakh sq. m. buildings completed. It has a guest house with 88 rooms, a 750-seater Auditorium, campus school, sports complex and hospital.

IIT Mandi has four Academic Schools and three major Research Centers. The Schools are: School of Computing and Electrical Engineering, School of Basic Sciences, School of Engineering, and School of Humanities and Social Sciences.

The Centers are: Advanced Materials Research Centre (AMRC; set up with an investment of Rs. 60 crores), Centre for Design and Fabrication of Electrical Devices (C4DFED; has Rs. 50 crores worth of fabrication tools), and BioX Centre (has acquired research equipment worth Rs. 15 crores).

In 2017, the Department of Biotechnology, Government of India, selected IIT Mandi to lead the prestigious Rs. 10 crore FarmerZone Project.

Top IITs for Mechanical Engineering offer a comprehensive curriculum covering mechanical engineering fundamentals.

Top IITs for Mechanical Engineering are known for their innovative and entrepreneurial culture.

Top IITs for Mechanical Engineering offer various specializations within Mechanical Engineering.

Top IITs for Mechanical Engineering are a popular choice among students seeking a career in Mechanical Engineering.

Details about top IITs for Mechanical Engineering in India are mentioned below for the sake of the students:

IIT Bombay

IIT Bombay is one of the top IITs in India, offering a well-established Mechanical Engineering program.

The institute has a strong faculty and research opportunities, with a focus on innovation and entrepreneurship.

IIT Bombay has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Robotics and Automation.

The institute has strong industry connections, providing students with internship and placement opportunities.

IIT Bombay is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

The institute has a well-established incubation center, supporting startups and entrepreneurship. This is also among the top IITs for Mechanical Engineering.

IIT Madras

IIT Madras is a top choice for Mechanical Engineering students, with a well-established program and strong industry connections.

The institute offers various specializations within Mechanical Engineering, including Thermal Engineering and Design Engineering.

IIT Madras has a strong research focus, with faculty and students working on projects in areas like nanotechnology and biomechanics.

The institute has a well-established incubation center, supporting startups and entrepreneurship.

IIT Madras is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals. This is also among the top IITs for Mechanical Engineering.

IIT Delhi

IIT Delhi is a top IIT in India, offering a well-established Mechanical Engineering program. The institute has a strong faculty and research opportunities, with a focus on innovation and entrepreneurship.

IIT Delhi has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Robotics and Automation.

The institute has strong industry connections, providing students with internship and placement opportunities.

IIT Delhi is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

The institute has a well-established incubation center, supporting startups and entrepreneurship. This is also among the top IITs for Mechanical Engineering.

IIT Kanpur

IIT Kanpur is a top choice for Mechanical Engineering students, with a well-established program and strong industry connections.

The institute offers various specializations within Mechanical Engineering, including Thermal Engineering and Design Engineering.

IIT Kanpur has a strong research focus, with faculty and students working on projects in areas like nanotechnology and biomechanics.

The institute has a well-established incubation center, supporting startups and entrepreneurship. IIT Kanpur is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals. This is also among the top IITs for Mechanical Engineering.

IIT Kharagpur

IIT Kharagpur is a top IIT in India, offering a well-established Mechanical Engineering program.

The institute has a strong faculty and research opportunities, with a focus on innovation and entrepreneurship.

IIT Kharagpur has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Robotics and Automation.

The institute has strong industry connections, providing students with internship and placement opportunities.

IIT Kharagpur is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

The institute has a well-established incubation center, supporting startups and entrepreneurship. This is also among the top IITs for Mechanical Engineering.

IIT Roorkee

IIT Roorkee is a top choice for Mechanical Engineering students, with a well-established program and strong industry connections.

The institute offers various specializations within Mechanical Engineering, including Thermal Engineering and Design Engineering.

IIT Roorkee has a strong research focus, with faculty and students working on projects in areas like nanotechnology and biomechanics.

The institute has a well-established incubation center, supporting startups and entrepreneurship. IIT Roorkee is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals. This is also among the top IITs for Mechanical Engineering.

IIT BHU Varanasi

IIT BHU Varanasi offers a well-established Mechanical Engineering program with a strong faculty and research opportunities.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Robotics and Automation.

IIT BHU Varanasi has strong industry connections, providing students with internship and placement opportunities.

The institute is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

IIT BHU Varanasi has a well-established incubation center, supporting startups and entrepreneurship.

The institute’s Mechanical Engineering program is accredited by the National Board of Accreditation (NBA). This is also among the top IITs for Mechanical Engineering.

IIT Guwahati

IIT Guwahati offers a well-established Mechanical Engineering program with a strong faculty and research opportunities.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Thermal Engineering and Design Engineering.

IIT Guwahati has strong industry connections, providing students with internship and placement opportunities.

The institute is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

IIT Guwahati has a well-established incubation center, supporting startups and entrepreneurship.

The institute’s Mechanical Engineering program is designed to provide students with a strong foundation in engineering principles and practices. This is also among the top IITs for Mechanical Engineering.

IIT Patna

IIT Patna offers a well-established Mechanical Engineering program with a strong faculty and research opportunities.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Robotics and Automation.

IIT Patna has strong industry connections, providing students with internship and placement opportunities.

The institute is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

IIT Patna has a well-established incubation center, supporting startups and entrepreneurship. The institute’s Mechanical Engineering program is accredited by the National Board of Accreditation (NBA). This is also among the top IITs for Mechanical Engineering.

IIT Indore

IIT Indore offers a well-established Mechanical Engineering program with a strong faculty and research opportunities.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Thermal Engineering and Design Engineering.

IIT Indore has strong industry connections, providing students with internship and placement opportunities.

The institute is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

IIT Indore has a well-established incubation center, supporting startups and entrepreneurship. The institute’s Mechanical Engineering program is designed to provide students with a strong foundation in engineering principles and practices. This is also among the top IITs for Mechanical Engineering.

IIT Mandi

IIT Mandi offers a well-established Mechanical Engineering program with a strong faculty and research opportunities.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Robotics and Automation.

IIT Mandi has strong industry connections, providing students with internship and placement opportunities.

The institute is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

IIT Mandi has a well-established incubation center, supporting startups and entrepreneurship. The institute’s Mechanical Engineering program is accredited by the National Board of Accreditation (NBA). This is also among the top IITs for Mechanical Engineering.

IIT Dharwad

IIT Dharwad offers a well-established Mechanical Engineering program with a strong faculty and research opportunities.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Thermal Engineering and Design Engineering.

IIT Dharwad has strong industry connections, providing students with internship and placement opportunities.

The institute is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

IIT Dharwad has a well-established incubation center, supporting startups and entrepreneurship.

The institute’s Mechanical Engineering program is designed to provide students with a strong foundation in engineering principles and practices. This is also among the top IITs for Mechanical Engineering.

IIT Jammu

IIT Jammu offers a well-established Mechanical Engineering program with a strong faculty and research opportunities.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Robotics and Automation.

IIT Jammu has strong industry connections, providing students with internship and placement opportunities.

The institute is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

IIT Jammu has a well-established incubation center, supporting startups and entrepreneurship. The institute’s Mechanical Engineering program is accredited by the National Board of Accreditation (NBA). This is also among the top IITs for Mechanical Engineering.

IIT (ISM) Dhanbad offers a well-established Mechanical Engineering program with a strong faculty and research opportunities.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Robotics and Automation.

IIT (ISM) Dhanbad has strong industry connections, providing students with internship and placement opportunities.

The institute is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

IIT (ISM) Dhanbad has a well-established incubation center, supporting startups and entrepreneurship.

The institute’s Mechanical Engineering program is accredited by the National Board of Accreditation (NBA). This is also among the top IITs for Mechanical Engineering.

IIT Palakkad

IIT Palakkad offers a well-established Mechanical Engineering program with a strong faculty and research opportunities.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Thermal Engineering and Design Engineering.

IIT Palakkad has strong industry connections, providing students with internship and placement opportunities.

The institute is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

IIT Palakkad has a well-established incubation center, supporting startups and entrepreneurship.

The institute’s Mechanical Engineering program is designed to provide students with a strong foundation in engineering principles and practices. This is also among the top IITs for Mechanical Engineering.

IIT (ISM) Dhanbad

IIT (ISM) Dhanbad offers a well-established Mechanical Engineering program with a strong faculty and research opportunities.

The institute has a comprehensive curriculum covering mechanical engineering fundamentals, with specializations in areas like Robotics and Automation.

IIT (ISM) Dhanbad has strong industry connections, providing students with internship and placement opportunities.

The institute is known for its innovative and entrepreneurial culture, with many successful startups emerging from the institute.

IIT (ISM) Dhanbad has a well-established incubation center, supporting startups and entrepreneurship.

The institute’s Mechanical Engineering program is accredited by the National Board of Accreditation (NBA). This is also among the top IITs for Mechanical Engineering.

Top IITs for Mechanical Engineering offer a comprehensive curriculum covering mechanical engineering fundamentals.

Top IITs for Mechanical Engineering have strong industry connections, providing students with internship and placement opportunities.

Top IITs for Mechanical Engineering are known for their innovative and entrepreneurial culture.

Top IITs for Mechanical Engineering have well-established incubation centers, supporting startups and entrepreneurship.

Top IITs for Mechanical Engineering offer various specializations within Mechanical Engineering.

Top IITs for Mechanical Engineering are renowned for their academic excellence and research opportunities

Also Read – Top 7 IITs For Management Courses in 2024: 2024 NIRF Ratings