ALS is a neurodegenerative disorder that severely affects voluntary movement of muscles and can lead to paralysis and death. It occurs due to changes in specific genes which may be triggered by factors such as smoking, exposure to toxins, metals and pesticides.

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The ‘ice bucket challenge,’ which went viral in the U.S. and the U.K. in 2014, created awareness about this disease among people. The disease is relatively unknown in India although Indians seem to have an earlier onset of this malady compared to people of the West and show longer lasting symptoms and disease progression.

Basant Kumar said One of the causes of ALS is the alterations in the genes that code for a critical protein called TDP-43. The gene alteration modifies the protein which results in its liquid-liquid phase separation. This phase separation in turn causes the proteins to be deposited on nerve cells, resulting in generalization.

‘We have shown that AIM4 prevents liquid-liquid phase separation of the modified protein, TDP-43-A315T. By this, AIM4 prevents aggregation of the protein and may potentially prevent the deposition on neurons.’

The research group compared the ability of AIM4 to prevent protein phase separation with that of other molecules such as Dimebon. Dimebon is an antihistamine that was studied for treatment of regenerative disorders by an American pharmaceutical company but failed clinical trials. The IIT Hyderabad Research team found that AIM4 was better than such earlier molecules in preventing protein phase separation.

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The research team has also discovered through computational studies that AIM4 has specific binding site on this protein and binding energy calculations have shown that the bond between AIM4 and the mutant protein is energetically favorable, which makes it a promising drug for potential treatment of ALS.

This work is an important step forward in the area of therapeutics of the regenerative disease ALS as current options for ALS are minimal or even non-existent, he said.

Submission started on 25 March 2027. Those who submit AP LAWCET 2025 application till from 25 March to 27 April 2025 need not pay the late fee.

This is about the exam to be taken for admission into graduate law courses in colleges across Andhra Pradesh.

Notification in connection with AP LAWCET Application Submission was released on 22 March 2025.

AP LAWCET 2025 Registration schedule

AP LAWCET 2025 registration schedule is the time duration during which students can apply for the exam, make corrections in the application form submitted, pay registration fee and so on. Submission started on 25 March 2025 and last date to apply without any late fee payment is 27 April 2025.

Students can take up AP LAWCET 2025 registration from 26 April to 3 May 2024 on payment of Rs 500 as late fee. They can apply for the exam from 4 to 11 May 2024 on the payment of Rs 1000 as late fee.

AP LAWCET 2025 registration can be done from 28-04-2025 to 04-05-2025 with a late fee of Rs 1000, as per AP LAWCET 2025 registration schedule.

The late fee to pay if submitted between 05-05-2025 to 11-05-2025 is Rs 2000. Students can take up AP LAWCET 2025 registration with a late fee of Rs 4000 from 12-05-2025 to 18-05-2025.

AP LAWCET 2025 registration can be done with a late fee for Rs 10000 from 19-05-2025 to 25-05-2025.

Correction in AP LAWCET 2025 applications already submitted can be done from 30 May 2025 onwards. Hall tickets would be available for download from 30 May 2025 onwards.

Exam will be conducted on 5 June 2025 from 9 AM to 10:30 AM. The result announcement will be done on 22 June 2025.

What is AP LAWCET 2025 Exam?

The full name of AP LAWCET is Andhra Pradesh Law Common Entrance Test. It is a state-level exam conducted once a year. AP LAWCET 2025 is meant to be held in 2025.

AP LAWCET 2025 is conducted in online mode and answers have to be registered on a computer screen provided at the test center. The test has to be passed with the required qualifying marks to be eligible for the next process.

Post passing the exams, candidates have to visit the websites of various participating institutions and know the schedule for submitting applications for admissions.

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Once the schedule is known, students must submit applications there along with AP LAWCET 2025 scores and other required documents.

The questions in the exam will be related to General Knowledge, Current Affairs, Law Study Aptitude, and Mental Ability for AP LAWCET 2025.

For studying 5 year law courses, applicants must have passed plus two from a recognized education institution. The plus two can be from any stream as per AP LAWCET 2025 registration eligibility criteria.

Those keen on LLB course must have passed graduation in any discipline from a recognized institution.

Students who have appeared for the final exams of their qualifying degree and are waiting for the results or are about to appear for final exams can also take up AP LAWCET 2025 registration.

However, they have to pass the exam and provide proof of it by the time of admission process commencement.

AP LAWCET 2025 registration process?

AP LAWCET 2025 registration process can be completed online. Candidates have to visit the official website at ‘https://cets.apsche.ap.gov.in/LAWCET/LAWCET/LAWCET_HomePage.aspx’

1. The URL mentioned above must be typed into the browser and then submitted to allow the website to download.

2. Once the website is ready, candidates have to click the button Step – 1 Eligibility Criteria And Fee Payment

3. Clicking the above button will open another webpage with URL ‘https://cets.apsche.ap.gov.in/LAWCET/LAWCET/LAWCET_PaymentGatewaypage.aspx’

4. Once the webpage with above URL is available, AP LAWCET 2025 registration fee must be paid.

5. Once the confirmation number is obtained, candidates can click the link for filling out the AP LAWCET 2025 Application form and submit it.

6. Post submission, candidates can obtain a confirmation message indicating successful submission. Once obtained, applicants can download it and take a printout of it.

Process to obtain hall ticket is mentioned below for the sake of the students:

1. The URL mentioned above has to be typed into the browser and the website should be allowed to download.

2. Once the webpage is available, candidates can click the link for the hall ticket and then enter their username and password and submit them to obtain the hall ticket.

3. The admit card can be downloaded and then a printout of it has to be taken. Applicants have to appear for the exam at the designated test center with the hall ticket.

After the exam

Students have to view the results for the exam, they can visit the official website of the exam at the appropriate time and log in using the credentials they created while taking up AP LAWCET 2025 registration.

Post login, the students can view their scorecards. Those who have passed the exam with the required qualifying marks can apply for admission into courses of their choice.

AP LAWCET 2025 registration process has to be done online and there is no other mode.