IISER Bhopal develops convenient strategy

IISER Bhopal develops convenient strategy
Published at : 7 Feb 2024, 6:45 PM IST
Updated at : 7 Feb 2024, 5:56 PM IST

IISER Bhopal researchers have developed a technology named ‘BHoPAL’ for attaching chemical tags to proteins, an important process in the development of drugs.

Through this technology, necessary chemical moieties can be linked to specific sites of a protein without harming the protein’s efficacy.

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IISER Bhopal

1. Attaching proteins to fluorescent chemical tags for their visualization inside cells enabling studies focused on understanding how they perform cellular functions.

2. Linking drugs to antibody proteins for selective drug delivery to diseased cells such as cancerous cells preventing undesirable side-effects of these drugs.

Proteins

Proteins are extremely prone to loss of function when treated with chemical reagents. However, for the first time, IISER Bhopal’s novel technique eliminates this problem.

Admission Open in SRM for 2025

This technology is called ‘Baylis Hillman orchestrated Protein Aminothiol Labelling’ (BHoPAL) which efficiently tags chemicals to proteins without compromising their function, say sources from IISER Bhopal.

IISER Bhopal

Their findings have been published in the reputed, peer-reviewed journal Nature Communications (https://doi.org/10.1038/s41467-024-45124-2).

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Objectives

Dr. Dimpy Kalia, Assistant Professor, Department of Chemistry, IISER Bhopal elaborated on the objectives of this research.

She said proteins are cellular entities that play crucial roles in all cellular functions.

Protein dysfunction results in major life-threatening diseases such as Alzheimer’s disease, Parkinson’s disease, etc.

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Hence, developing effective approaches to study proteins in cells is crucial for developing therapeutic approaches targeting them, said Dr Kalia of IISER Bhopal.

Test

To test this platform, the researchers developed a new chemical reaction that has never been explored before.

This reaction occurs between N-Cysteine, an important amino acid present in proteins, and Baylis Hillman adducts, and results in the formation of a linkage (a bis-heterocyclic scaffold) on specific sites on the protein, say IISER Bhopal researchers.

Labelling multiple sites of a protein is extremely difficult, but by using this approach, researchers can easily accomplish this task within a few minutes, say IISER Bhopal researchers.

Diverse Applications

Elaborating further, Dr. Dimpy Kalia of IISER Bhopal said, “What we have developed has diverse applications in chemical biology, synthetic chemistry, and medicinal chemistry.

Protein conjugates fabricated using our BHoPAL technology shall be employed for the fabrication of antibody-drug conjugates (ADCs) for cancer therapy, said Dr Dimpy of IISER Bhopal.

Moreover, the BHoPAL technology shall also contribute tremendously to basic biological research by enabling the imaging of proteins within human cells, said Dr Dimpy.

IISER Bhopal

This is a promising development that shall find applications in disease diagnosis, cellular imaging, drug development, and understanding drug-target interactions on a molecular level.

About IISER Bhopal

Established by the Ministry of Education (then Ministry of Human Resource & Development), Government of India, in 2008.

IISER Bhopal is the youngest of the first five IISERs. In a decade, the Institute has received several distinctions, duly carving out its position in the national and international arena.

With a vision to provide high-quality education to students and contribute to society through its research, IISER Bhopal is the first IISER to have been declared by the Ministry of Education for project completion.

IISER Bhopal is continuously consolidating its position in the National and International rankings and has secured 60th place in The National Institutional Ranking Framework, Ministry of Education, Government of India.

Along with this, IISER Bhopal was placed at rank 4th in India (Academic sector) in the Nature Index Rank 2023 and rank 281-290 in the overall category of the QS Asia Ranking 2023.

The Institute has also been ranked 57th (National Rank, out of 70 in the 1500 Institutes) in the Times Higher Education 2023 World Ranking.

 

S.
S. Vishnu Sharma

S Vishnu Sharmaa now works with collegechalo.com in the news team. His work involves writing articles related to the education sector in India with a keen focus on higher education issues. Journalism has always been a passion for him. He has more than 10 years of enriching experience with various media organizations like Eenadu, Webdunia, News Today, Infodea. He also has a strong interest in writing about defence and railway related issues.

JEE Mains 2025 Application On till 25 February 2025 For 2nd Session, All Information Available Here

JEE Mains 2025 Application On till 25 February 2025 For 2nd Session, All Information Available Here
Published at : 16 Feb 2025, 9:33 PM IST
Updated at : 16 Feb 2025, 9:33 PM IST

JEE Mains 2025 Application submission for the second session is going on till 25 February 2025 at ‘https://jeemain.nta.nic.in/’

The application submission began on 1 February 2025. Students who could not undertake JEE Mains 2025 Application submission for the first session can undertake the same during the second session.

Admission Open in Amity for 2025

This is one of the well-known competitive exams in India that sees registration of more than six lakh students every year. JEE Mains 2025 Application is for the second session now.

JEE Mains 2025 Application

Admit cards will be available about three days before the actual date of the examination of the applicant. Exam will be conducted from 1 to 8 April 2025 tentatively.

Results for the second session are to be released by 17 April 2025. There is more to it than meets the eye as far as JEE Mains 2025 Application submission is concerned.

Admission Open in SRM for 2025
JEE Mains 2025 Application

The exam will have three papers, Paper 1, Paper 2A, Paper 2B. Paper 1 of JEE Mains 2025 is for students focused on graduation in engineering (BE or BTech).

Students keen on studying under graduation in architecture (BArch) have to appear for Paper 2A, those who wish to study graduation in planning (BPlan) have to appear for Paper 2B.

Admission Open in LPU for 2025

Architecture aspirants have also to answer questions related to creativity, innovation, drawing along with that of maths, physics and chemistry.

Format of questions will be multiple choice where every question has more than one reply option and the right one has to be chosen for getting marks.

Who can submit JEE Mains 2025 Application?

Students who have passed plus-two from a recognized educational institution with subjects as maths, physics and chemistry can take up JEE Mains 2025 application submission.

Even students who have appeared for the plus-two exams and are waiting for results or who are about to appear for the qualifying exam can also submit JEE Mains 2025 application.

Admission Open in VIT for 2025

However, these students have to pass the exam and provide proof of it by the time of admission. Not able to do, may lead to cancellation of admission.

JEE Mains 2025 Application Fee

The url to access the official website for submitting applications is ‘https://jeemain.nta.ac.in/’

1. The URL mentioned above has to be typed into the browser and submitted to allow the website to download.

2. Once the website is ready, candidates can read all the information about the exam.

3. After knowing everything about the exam, candidates can scroll down the webpage and click JEE(Main)-2025 Session-2 Registration

4. Clicking the above button opens another webpage with URL ‘https://examinationservices.nic.in/JeeMain2025/root/Home.aspx?enc=WPJ5WSCVWOMNiXoyyomJgDUffqDdG1LTsAPBKFcEC9W88CTkt2ITzilIsFR7gKxO’

5. Once the webpage with above URL opens, candidates have to press New Registration on the left side and create an account with username and password.

6. After registration, come back to the same webpage with the same URL mentioned in Point No 4 and type the username and password on the right side and sign in to fill the JEE Mains 2025 Application.

Point to remember

Candidates who have already submitted applications for the first session, can directly login and apply for the second session. However, those applying for the second session freshly, have to register and create credentials to login and submit JEE Mains 2025 application for second session.

Post application submission

Individuals who have submitted their JEE Mains 2025 application successfully can download their admit card about three days before they are to appear for the exam.

JEE Mains 2025 Application submission rules

1. Type the URL mentioned above in the browser and submit it to allow the website to download.

2A. After the website is available, candidates can click the link for admit card and then enter their credentials created during the registration and submit them to view the admit card.

2B. Candidates can also click the registration link for the exam and login using the credentials created during the initial registration to view the admit card.

3. After the admit card is visible, candidates can download and take a printout.

Exam

Candidates have to appear for the exam and then pass it with the required qualifying marks which are also known as cutoff marks.

Students who pass the exam with the required score can take part in the counselling process to obtain seats in NITs, IIITs or IIITDMs.

Those willing to study in IITs have to pass JEE Mains with a score that falls under top 2.5 lakh ranks on a national level to apply for JEE Advanced, a written test required to qualify for admission into IITs.

S.
S. Vishnu Sharma

S Vishnu Sharmaa now works with collegechalo.com in the news team. His work involves writing articles related to the education sector in India with a keen focus on higher education issues. Journalism has always been a passion for him. He has more than 10 years of enriching experience with various media organizations like Eenadu, Webdunia, News Today, Infodea. He also has a strong interest in writing about defence and railway related issues.



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