Through this technology, necessary chemical moieties can be linked to specific sites of a protein without harming the protein’s efficacy.

1. Attaching proteins to fluorescent chemical tags for their visualization inside cells enabling studies focused on understanding how they perform cellular functions.

Proteins

Proteins are extremely prone to loss of function when treated with chemical reagents. However, for the first time, IISER Bhopal’s novel technique eliminates this problem.

This technology is called ‘Baylis Hillman orchestrated Protein Aminothiol Labelling’ (BHoPAL) which efficiently tags chemicals to proteins without compromising their function, say sources from IISER Bhopal.

Their findings have been published in the reputed, peer-reviewed journal Nature Communications (https://doi.org/10.1038/s41467-024-45124-2).

Objectives

Dr. Dimpy Kalia, Assistant Professor, Department of Chemistry, IISER Bhopal elaborated on the objectives of this research.

She said proteins are cellular entities that play crucial roles in all cellular functions.

Protein dysfunction results in major life-threatening diseases such as Alzheimer’s disease, Parkinson’s disease, etc.

Also read – IIT Delhi’s Launches Healthcare Executive Programme : 120-Hour Pathway to Success

Hence, developing effective approaches to study proteins in cells is crucial for developing therapeutic approaches targeting them, said Dr Kalia of IISER Bhopal.

Test

To test this platform, the researchers developed a new chemical reaction that has never been explored before.

This reaction occurs between N-Cysteine, an important amino acid present in proteins, and Baylis Hillman adducts, and results in the formation of a linkage (a bis-heterocyclic scaffold) on specific sites on the protein, say IISER Bhopal researchers.

Labelling multiple sites of a protein is extremely difficult, but by using this approach, researchers can easily accomplish this task within a few minutes, say IISER Bhopal researchers.

Diverse Applications

Elaborating further, Dr. Dimpy Kalia of IISER Bhopal said, “What we have developed has diverse applications in chemical biology, synthetic chemistry, and medicinal chemistry.

Protein conjugates fabricated using our BHoPAL technology shall be employed for the fabrication of antibody-drug conjugates (ADCs) for cancer therapy, said Dr Dimpy of IISER Bhopal.

Moreover, the BHoPAL technology shall also contribute tremendously to basic biological research by enabling the imaging of proteins within human cells, said Dr Dimpy.

This is a promising development that shall find applications in disease diagnosis, cellular imaging, drug development, and understanding drug-target interactions on a molecular level.

About IISER Bhopal

Established by the Ministry of Education (then Ministry of Human Resource & Development), Government of India, in 2008.

IISER Bhopal is the youngest of the first five IISERs. In a decade, the Institute has received several distinctions, duly carving out its position in the national and international arena.

With a vision to provide high-quality education to students and contribute to society through its research, IISER Bhopal is the first IISER to have been declared by the Ministry of Education for project completion.

IISER Bhopal is continuously consolidating its position in the National and International rankings and has secured 60^th place in The National Institutional Ranking Framework, Ministry of Education, Government of India.

Along with this, IISER Bhopal was placed at rank 4^th in India (Academic sector) in the Nature Index Rank 2023 and rank 281-290 in the overall category of the QS Asia Ranking 2023.

The Institute has also been ranked 57^th (National Rank, out of 70 in the 1500 Institutes) in the Times Higher Education 2023 World Ranking.

Registration started from 1 March 2025. There is more to it than meets the eye.

It is all about registration for two exams – TG LAWCET 2025 and TG PGLCET 2025.

These exams are also known as TS LAWCET and TS PGLCET. TG LAWCET/ PGLCET 2025 application submission can be done till 25 April 2025 with a payment of late fee of Rs 500.

TG LAWCET/PGLCET 2025 application submission can be done till 5 May 2025 with a late fee of Rs 1000. The date to apply is 15 May 2025 with a late fee payment of Rs 2000.

Candidates can take up TG LAWCET/PGLCET 2025 application submission till 25 May 2025 with a late fee of Rs 4000.

Those who have successfully completed TG LAWCET/PGLCET 2025 application submission can take up corrections in their application from 20 to 25 May 2025.

Hall tickets will be available for download from 30 May 2025 onwards. TG LAWCET will be conducted on 6 June 2025.

Preliminary key will be out on 10 June 2025, last date to submit objections on preliminary key is 14 June 2025 and announcement of final key and results will be done on 25 June 2025.

Osmania University will conduct TG LAWCET, PGLCET 2025 exams on behalf of Telangana State Council for Higher Education (TSCHE).

Individuals have to pass TG LAWCET, PGLCET 2025 with minimum qualifying marks also known as cutoff scores.

They are the minimum marks candidates have to score in the exam to be eligible for further process.

Scores of the candidates in TG LAWCET, PGLCET 2025 must be either greater than the cutoff marks or equal to them to be eligible for further process. The further process likely involves counselling and document verification.

What are TG LAWCET, PGLCET 2025 exams?

The full name of TG LAWCET is Telangana State Law Common Entrance Test, and the same for TG PGLCET is Telangana State PG Law Common Entrance Test. Both together are known as Telangana State Law & PG Law Common Entrance Test.

It is a state-level entrance test that is conducted once a year. TG LAWCET, PGLCET 2025 is meant to be conducted this year (2025).

TG LAWCET, PGLCET 2025 will be conducted online where answers have to be marked on a computer.

The format of questions is multiple choice, where each question will have more than one option and the right one has to be chosen to get the marks.

TG LAWCET 2025 will have questions related to Current Affairs, General Knowledge, Mental Ability, and Aptitude for the Study of Law.

TG PGLCET 2025 will have questions related to law lessons taught in graduate law classes like Constitutional Law, Public International Law, and Mercantile Law.

Who can submit TG LAWCET/PGLCET 2025 application?

Candidates aiming for under graduate law courses can apply for TG LAWCET 2025, while those aiming for post graduate law courses can register for TG PGLCET 2025.

TG LAWCET/PGLCET 2025 application submission is applying for either one of these exams.

The eligibility to apply for TG LAWCET 2025 is a pass in plus two in any stream from a recognized educational institution. Students who have passed graduate law courses can apply for TG PGLCET 2025.

Those willing to take up TG LAWCET, PGLCET 2025 registration must be natives of Telangana or Andhra Pradesh.

They should satisfy local/non–local status requirements as laid down in the Telangana /Andhra Pradesh Education Institutions (Regulations of Admission) order, 1974 as subsequently amended.

How to submit TG LAWCET/PGLCET 2025 application submission?

The process to take up TG LAWCET/PGLCET 2025 application submission is online and candidates have to visit the official website of the exam to submit applications. The URL to reach it is ‘https://lawcet.tgche.ac.in/’

1. The URL mentioned above has to be typed into the browser of the computer and the website has to be allowed to download.
2. Once the webpage is available, applicants for LAWCET or PGLCET have to click the required link and pay the registration fee and obtain the confirmation number.
3. Once the confirmation number is obtained, candidates can click the link for filling out the application form and start providing all the information on that.
4. Applicants targeting graduate law course admission can opt for filling TS LAWCET 2025 application, and those aiming for post-graduate law course admission can opt for filling TG PGLCET 2025 application.
5. The application has to be filled out and submitted.
6. Post submission, candidates can obtain a confirmation message indicating successful submission.
7. Once obtained, applicants can download it and take a printout of it.

Link for TG LAWCET/PGLCET 2025 application submission is here

After TG LAWCET/PGLCET 2025 application submission

Hall tickets have to be downloaded, they will be made available for download from 30 May 2025 onwards.

Students who have successfully completed their TG LAWCET/PGLCET 2025 application submission alone can download their hall tickets.

Students have to appear for TG LAWCET and PGLCET 2025 on 6 June 2025.

The tests have to be passed with the required qualifying marks to be eligible for the next process which involves counselling and document verification.

The results of TS LAWCET/PGLCET will be displayed on the official website and dates for that will be announced in due course. Students who pass TG LAWCET and PGLCET exams with the required qualifying marks can apply for further admission process.

Those who get a seat in the course of their choice can convey their acceptance and pay the fees and join the classes. The details can be accessed from the official website of the exam or those of the participating institutions.

Also Read – Top 20 Law Colleges in India in 2024 As Per 2024 NIRF Rank